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目的探讨早产儿早期应用不同剂量脂肪乳剂对临床情况的影响。方法将本院2010年3～10月胎龄30～34周、体重1200～2000g的早产儿60例随机分为2组,观察组出生24h后给予脂肪乳剂1.0g/(kg.d),每天增加1.0g/kg至足量,对照组出生24h后给予脂肪乳剂0.5g/(kg.d),每天增加0.5g/kg至足量。观察两组临床情况、血小板计数、血脂及肝功能,并作对比分析。结果观察组恢复出生体重时间、平均胃肠外营养时间均短于对照组[(4.5±0.9)天比(6.6±1.1)天,(6.9±1.6)天比(8.8±2.4)天,P均<0.05];两组发生高胆红素血症日龄、黄疸持续时间、血小板计数、血脂及肝功能差异均无统计学意义(P均>0.05)。结论早产儿早期应用较大剂量脂肪乳不影响体内胆红素代谢,不引起出血、高脂血症、胆汁淤积等并发症,并且可以缩短恢复至出生体重时间及胃肠外营养时间。
Objective To investigate the effect of different doses of fat emulsion on the clinical situation in early stage of preterm infants. Methods From March to October 2010, 60 preterm infants with gestational age of 30 to 34 weeks and body weight of 1200 to 2000g were randomly divided into two groups. The observation group was given 1.0g / (kg.d) Increase 1.0g / kg to the full amount, the control group was given fat emulsion 0.5g / (kg.d) 24 hours after birth, increase 0.5g / kg every day to a sufficient amount. Two groups were observed clinical situation, platelet count, blood lipid and liver function, and for comparative analysis. Results The birth weight and average parenteral nutrition time in observation group were shorter than those in control group [(4.5 ± 0.9) days vs (6.6 ± 1.1 days), (6.9 ± 1.6 days vs 8.8 ± 2.4 days, P <0.05]. There was no significant difference in age, duration of jaundice, platelet count, blood lipid and liver function between the two groups (all P> 0.05). Conclusion The higher dose of fat emulsion in the early stage of preterm infants does not affect the metabolism of bilirubin in the body, does not cause complications such as bleeding, hyperlipidemia and cholestasis, and can shorten the time from recovery to birth weight and parenteral nutrition.