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目的:探讨老年患者应用抗生素引起不良反应的临床特点,分析相关危险因素。方法:我院收治的老年患者300例,均服用抗生素。统计患者不良反应及危险因素。结果:β内酰胺类易引起变态反应、菌群失调、腹泻及其它;喹诺酮类和大环内酯类容易对肝肾产生损伤;氨基糖苷类容易产生肾毒性和变态反应。年龄、住院时间、用药时间、用药方式均是引起不良反应的危险因素(P<0.05)。结论:老年患者应用抗生素出现的不良反应较多,注意临床规范用药。
Objective: To explore the clinical features of adverse reactions caused by antibiotics in elderly patients and to analyze the related risk factors. Methods: 300 cases of elderly patients admitted to our hospital, taking antibiotics. Statistics of patients with adverse reactions and risk factors. Results: β-lactams easily lead to allergies, flora, diarrhea and other; quinolones and macrolides prone to liver and kidney damage; aminoglycosides prone to renal toxicity and allergy. Age, length of hospital stay, duration of medication and mode of administration were all risk factors for adverse reactions (P <0.05). Conclusion: There are many adverse reactions in elderly patients with antibiotics, pay attention to clinical norms medication.