肿瘤坏死因子相关凋亡诱导配体(TRAIL)是肿瘤坏死因子(TNF)超家族成员之一,能选择性的诱导肿瘤细胞、转化细胞凋亡,而对正常组织无毒性,有望成为肿瘤治疗的新方法,备受人们的关注。本文从TRAIL的结构、受体、诱导肿瘤细胞凋亡机制及在肿瘤治疗中的应用等方面作了介绍,以期为TRAIL临床应用提供参考。 Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a member of the tumor necrosis factor (TNF) superfamily, selectively induces tumor cells and translocates the cells to apoptosis, but is non-toxic to normal tissues and is expected to become a tumor therapy The new method, attracts people’s attention. This article describes the structure of TRAIL, the receptor, the mechanism of apoptosis induced in tumor cells and its application in the treatment of cancer, in order to provide a reference for the clinical application of TRAIL.