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目的探讨sICAM-1在高白细胞急性白血病(HLAL)患者中的表达及临床意义。方法采用ELISA法检测30例HLAL患者及20例非HLAL患者血清sICAM-1的表达水平,同时选择20例健康查体者作为对照组。结果治疗前后HLAL和非HLAL患者血清sICAM-1水平显著高于对照组,HLAL组患者血清sICAM-1水平高于非HLAL组患者。结论 sICAM-1在HLAL患者中的异常表达可能在HLAL的发生、发展中发挥了重要作用。
Objective To investigate the expression and clinical significance of sICAM-1 in patients with high white blood cell acute leukemia (HLAL). Methods The serum levels of sICAM-1 in 30 patients with HLAL and 20 patients with non-HLAL were detected by ELISA. Twenty healthy people were selected as the control group. Results Serum levels of sICAM-1 in HLAL and non-HLAL patients before and after treatment were significantly higher than those in control group. Serum levels of sICAM-1 in HLAL patients were higher than those in non-HLAL patients. Conclusion The abnormal expression of sICAM-1 in HLAL patients may play an important role in the occurrence and development of HLAL.