1,18-十八烯-(9)-二酸是某些植物的次生代谢产物,在合成塑料、涂料及香料等方面有广泛用途。由于该酸有一个不饱和双键,所以用化学合成法获得该α,ω-二酸是比较困难的。我们在研究中发现一株Candida tropicalts多倍体突变种能选择性地氧化十八烯-(9)-一酸的甲基末端,生成1,18-十八烯-(9)-二酸。经过试验,发酵120小时后,加硫酸酸化至pH 1～2,用乙醚提取得1,18-十八烯-(9)-二酸 1,18-octadecene- (9) -dioxacid is a secondary metabolite of some plants and has a wide range of applications in the fields of synthetic plastics, paints and fragrances. As the acid has an unsaturated double bond, it is more difficult to obtain the α, ω-diacid by chemical synthesis. In our study, we found that a Polyploid mutant of Candida tropicalts can selectively oxidize the methyl end of octadecene- (9) -monoacid to produce 1,18-octadecene- (9) -dioic acid. After the test, fermentation 120 hours, add sulfuric acid to pH 1 ~ 2, extracted with ether 1,18-octadecene - (9) - diacid