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目的观察鼻塞持续气道正压呼吸(CPAP)治疗新生儿呼吸衰竭的临床疗效。方法 106例呼吸衰竭新生儿随机分为两组,观察组53例采用CPAP治疗,对照组53例给予头罩吸氧,比较两组的临床疗效及治疗前后血气的变化。结果观察组的总有效率为79.2%,明显高于对照组的56.6%(P<0.05);观察组治疗后pH值为7.35±0.18,动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)分别为(10.42±2.67)、(6.22±1.59)kPa,动脉血氧饱和度(SaO2)为(96.85±15.58)%,而对照组pH值为(7.29±0.17),PaO2、PaCO2分别为(7.11±1.52)、(6.15±1.57)kPa,SaO2为(83.26±12.71)%;与治疗前比较,两组治疗后PaO2和SaO2水平明显升高(P<0.05),而pH值及PaCO2水平差异无统计学意义;观察组治疗后PaO2和SaO2水平明显高于同期对照组(P<0.05)。结论采用CPAP对呼吸衰竭新生儿进行治疗,能够明显提高疗效,改善缺氧状态。
Objective To observe the clinical efficacy of nasal continuous positive airway pressure (CPAP) in the treatment of neonatal respiratory failure. Methods 106 newborns with respiratory failure were randomly divided into two groups. In the observation group, 53 cases were treated with CPAP, while 53 cases in the control group were given oxygen mask. The clinical efficacy and blood gas changes before and after treatment were compared between the two groups. Results The total effective rate in the observation group was 79.2%, significantly higher than that in the control group (56.6%, P <0.05). After treatment, the pH value of the observation group was 7.35 ± 0.18, the PaO2 and the arterial partial pressure of carbon dioxide (PaCO2) were (10.42 ± 2.67) and (6.22 ± 1.59) kPa respectively, and SaO2 was (96.85 ± 15.58)%, while the control group was (7.29 ± 0.17) PaO2 and PaCO2 respectively (7.11 ± 1.52) and (6.15 ± 1.57) kPa, and the SaO2 was (83.26 ± 12.71)%. PaO2 and SaO2 levels in the two groups were significantly higher than those before treatment (P <0.05) The level of PaO2 and SaO2 in the observation group was significantly higher than that in the control group (P <0.05). Conclusion CPAP treatment of neonatal respiratory failure can significantly improve the efficacy and improve hypoxia.