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目的:分析肺癌转移相关性急性胰腺炎（MIAP）患者的临床特征及预后，为临床早期诊断提供线索。方法:回顾性分析2002年1月至2019年9月北京协和医院收治的8例肺癌MIAP患者病例特点及转归，并与非肿瘤所致急性胰腺炎（AP）进行比较。结果:7例（7/8）为轻症AP，1例（1/8）为重症AP。4例（4/8）以AP为首发表现，自AP起病至肺癌确诊平均时间为（112±36）d。临床表现以腹痛（8/8）为主，其次为消瘦（4/8）、恶心呕吐（2/8）、梗阻性黄疸（1/8）等。肺癌分期均为Ⅳ期，7例（7/8）为小细胞肺癌，1例（1/8）为低分化腺癌。中位生存期11个月。与非肿瘤所致AP对比，肺癌MIAP患者年龄更大[（62±9）岁比（48±15）岁，n P=0.018）]，主胰管扩张（37.5%比3.1%，n P=0.004）和腹腔淋巴结肿大（37.5%比6.3%，n P=0.017）发生率更高；血红蛋白[（105.3±15.6）g/L比（147.9±24.8）g/L，n P<0.001）]和红细胞压积（31.4±5.3比42.5±6.1，n P<0.001）更低。n 结论:肺癌MIAP预后较差，症状不特异。老年、贫血、主胰管扩张和腹腔淋巴结肿大是其诊断线索，诊疗中应予以重视。“,”Objective:To analyze the clinical features and prognosis of lung cancer patients with metastasis-induced acute pancreatitis (MIAP), and to provide clues for early diagnosis.Methods:The characteristics and prognosis of 8 patients with MIAP in lung cancer admitted to Peking Union Medical College Hospital from January 2002 to September 2019 were retrospectively analyzed and were compared with non-tumor-induced AP.Results:Sevencases(7/8) were Mild AP, one (1/8) was Severe AP. Four patients (4/8) presented with AP as the reporting sign and lung cancer was not diagnosed until (112±36) days after the onset of AP. Clinical manifestations included abdominal pain (8/8), weight loss (4/8), nausea and vomiting (2/8), and jaundice (1/8). Stages of lung cancer were all Ⅳ.Histopathology proved that seven cases (7/8) were small cell lung cancer, and one case (1/8) was poorly differentiated adenocarcinoma. The median survival time was 11 months. Compared with non-tumor-induced AP, lung cancer patients with MIAP were older[(62±9) vs (48±15), n P=0.018], the incidence of primary pancreatic duct dilatation (37.5% vs 3.1%, n P=0.004) and abdominal lymphadenopathy (37.5% vs 6.3%, n P=0.017) were higher; the level of hemoglobin [105.3±15.6) g/L vs (147.9±24.8) g/L, n P<0.001] and hematocrit [(31.4±5.3) vs (42.5±6.1), n P<0.001] were lower.n Conclusions:Patientswith MIAP in lung cancer had poor outcome and unspecific symptoms. Old age, anemia, main pancreatic duct dilatation and abdominal lymphadenopathy are diagnostic clues that merit clinical attention.