论文部分内容阅读
目的观察溴隐停、二甲双胍、罗格列酮分别对多囊卵巢综合征(polycystic ovary syndrome,P-COS)大鼠胰岛素抵抗和性激素作用。方法采用十一酸睾酮加绒促性素(human chorionic gonado-tropin,HCG)建立PCOS大鼠模型,连续经口给予溴隐停、二甲双胍、罗格列酮6周,测定大鼠空腹血糖(fasting blood glucose,FBG)、经口给予葡萄糖后2 h血糖(2-hours blood glucose after oral glucosetolerance test,OGTT-2hBG)、胰岛素(insulin,Ins)、肿瘤坏死因子-α(tumor necrosis factor,TNF-α)、睾酮(testosterone,T)、胰岛素样生长因子(insulin growth factor-I,IGF-I)、雌激素(estradiol,E2)、孕酮(progesterone,P)、泌乳素(prolactin,PRL)等含量,并计算胰岛素敏感指数(insulin sensitivity index,ISI)的变化。结果 PCOS大鼠FBG、OGTT-2hBG、Ins、TNF-α、IGF-I、T、E2和PRL水平明显升高,而ISI和P显著降低,与空白对照组比较,差异有高度显著性(P<0.01);溴隐停、二甲双胍、罗格列酮均能不同程度地改善PCOS大鼠的上述病理改变(P<0.01~0.05)。结论溴隐停、二甲双胍、罗格列酮均能不同程度地改善PCOS大鼠胰岛素抵抗(insulin resistance,IR)和性激素分泌异常,降低T含量。
Objective To observe the effects of bromocriptine, metformin and rosiglitazone on insulin resistance and sex hormone in polycystic ovary syndrome (P-COS) rats. Methods PCOS rat model was established by using HCG (HCG). The rats were administered orally with bromocriptine, metformin and rosiglitazone for 6 weeks. The fasting blood glucose blood glucose (FBG), 2-hour blood glucose after oral glucosetolerance test (OGTT-2hBG), insulin (Ins), tumor necrosis factor-α , Testosterone (T), insulin-like growth factor-I (IGF-I), estradiol (E2), progesterone (P), prolactin (PRL) , And calculated insulin sensitivity index (ISI) changes. Results The levels of FBG, OGTT-2hBG, Ins, TNF-α, IGF-I, T, E2 and PRL in PCOS rats were significantly higher than those in the blank control group <0.01). Bromocriptine, metformin and rosiglitazone all improved the above pathological changes in PCOS rats (P <0.01 ~ 0.05). Conclusion Bromocriptine, metformin and rosiglitazone can both improve the insulin resistance (IR) and sex hormone secretion abnormalities and reduce the content of T in PCOS rats.