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目的探讨液基薄层细胞技术(LCT)在宫颈病变筛查中的应用。方法对5615例门诊受检者的宫颈细胞采用LCT技术检测和TBS分类诊断,将诊断意义不明的不典型鳞状细胞(ASCUS)以上病变均列为细胞阳性病例,进行阴道镜下多点取材活检,以病理学结果为金标准,传统宫颈刮片巴氏染色结果作对照分析。结果LCT法阳性病例总检出率9.68%,阳性率和准确率显著优于传统巴氏涂片,阳性病例与病理检查结果相符。结论LCT技术比传统的巴氏染色法更能准确、全面地反映宫颈癌和癌前病变,提高了各种宫颈阴道细胞学疾病的检出率及准确性。
Objective To investigate the application of liquid-based thin-layer cytology (LCT) in screening cervical lesions. Methods Cervical cells of 5615 outpatients were diagnosed by LCT and TBS. All the above lesions with atypical diagnosis of atypical squamous cell carcinoma (ASCUS) were classified as cell positive cases, colposcopy multipoint biopsy , The pathological results for the gold standard Pap test results of the traditional cervical scraps for control analysis. Results The positive rate of LCT positive cases was 9.68%. The positive rate and accuracy were significantly better than those of traditional Pap smears. The positive cases were consistent with the pathological findings. Conclusion LCT is more accurate and comprehensive than classical Papanicolaou staining in cervical cancer and precancerous lesions, and improves the detection rate and accuracy of cervical vaginal diseases.