氯卡胺系一抗心律失常药。本文用兔主动脉环研究了该药对NE,KCl,和CaCl_2诱发收缩的影响。结果表明氯卡胺显著降低NE 0.1μmol/L和KCl60mmol/L诱发的收缩,且非竞争性抑制NE浓度-效应曲线,pD′_2为3.6;竞争性抑制CaCl_2浓度-效应曲线,PA_2为4.6,从而提示氯卡胺抗复灌性心律失常作用可能与阻断α受体和电位依赖Ca~(2+)通道有关。 Chlorcamamine is an antiarrhythmic drug. In this study, rabbit aortic rings were used to study the effect of the drug on NE, KCl, and CaCl 2 -induced contraction. The results showed that chlorocacamide significantly reduced the contraction induced by NE 0.1 μmol/L and KCl60 mmol/L, and non-competitive inhibition of NE concentration-effect curve, pD′_2 was 3.6; competitive inhibition of CaCl_2 concentration-effect curve, PA_2 was 4.6, This suggests that the anti-reperfusion arrhythmia effect of chlorokaine may be related to blocking α-receptors and potential-dependent Ca 2+ channels.