论文部分内容阅读
目的寻找肝硬化单纯腹水与合并自发性腹膜炎(SBP)的临床鉴别指标。方法选取27例肝硬化腹水合并SBP患者(观察组)及32例单纯肝硬化腹水患者(对照组),抽取清晨空腹时静脉血10 mL,采用全自动生化分析仪检测两组血常规、肝功能指标[ALT、AST、TBIL、ALB、前白蛋白(PA)]、血清总胆固醇(TCH)、血清CRP,采用自动血凝分析仪检测血浆凝血酶原时间(PT)。两组均经腹腔穿刺抽取腹水60 mL,全自动生化分析仪检测腹水常规和生化。结果两组肝功能指标、TCH及PT比较,P均>0.05;两组血WBC及中性粒细胞比例、腹水WBC、ALB比较,P均>0.05。观察组腹水中性粒细胞比例、血清/腹水蛋白梯度、血清CRP分别为70.69%±12.0%、(19.59±3.51)g/L、(16.59±12.34)mg/L,对照组26.94%±13.56%、(21.87±3.28)g/L、(10.57±9.45)mg/L,两组比较,P均<0.05。结论腹水常规中性粒细胞比例、血清/腹水蛋白梯度、血清CRP可以作为鉴别诊断肝硬化单纯腹水与合并SBP的指标。
Objective To find clinical differential indexes of ascites caused by cirrhosis and spontaneous peritonitis (SBP). Methods Twenty-seven patients with cirrhosis with ascites and SBP (observation group) and 32 patients with cirrhosis and ascites (control group) were enrolled in this study. Venous blood 10 mL was collected in fasting morning, and the blood and liver function were detected by automatic biochemical analyzer (ALT, AST, TBIL, ALB, prealbumin (PA)], serum total cholesterol (TCH) and serum CRP were measured. Plasma prothrombin time (PT) was measured by automatic hemagglutination analyzer. Both groups were peritoneal ascites aspiration 60 mL, automatic biochemical analyzer ascites routine and biochemical testing. Results The indexes of hepatic function, TCH and PT of the two groups were all> 0.05. The ratio of WBC and neutrophil, WBC and ALB in ascites were higher in both groups (P> 0.05). The ascites neutrophil ratio, serum / ascites protein gradient and serum CRP in the observation group were respectively 70.69% ± 12.0%, (19.59 ± 3.51) g / L, (16.59 ± 12.34) mg / L and 26.94% ± 13.56% , (21.87 ± 3.28) g / L and (10.57 ± 9.45) mg / L, respectively, P <0.05. Conclusion Astrocyte routine neutrophil ratio, serum / ascites protein gradient, serum CRP can be used as a differential diagnosis of cirrhosis ascites and combined with SBP indicators.