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研究支气管哮喘患儿血清－氧化氮（ＮＯ）的变化及其临床意义。方法采用镀铜镉还原法和放射免疫法测定患者血清ＮＯ２／ＮＯ３和ｃＧＭＰ的含量。结果哮喘急性发作期血清ＮＯ２／ＮＯ３和ｃＧＭＰ含量明显高于对照组（Ｐ均＜０．０１）；缓解期的含量低于急性发作期（Ｐ＜０．０１和Ｐ＜０．０５），与对照组相比，差异无显著性。结论哮喘急性发作期ＮＯ的生长增多，参与哮喘的发病过程；血清ＮＯ的测定可作为判断治疗效果的一个指标。
To study the changes of serum nitric oxide (NO) in children with bronchial asthma and its clinical significance. Methods The contents of NO2 / NO3 and cGMP in serum were determined by copper-cadmium reduction and radioimmunoassay. Results Serum levels of NO2 / NO3 and cGMP were significantly higher in patients with acute exacerbation of asthma (P <0.01, P <0.01 and P <0.05, respectively) than those in acute exacerbation Compared with the control group, the difference was not significant. Conclusions The growth of NO is increased during acute exacerbation of asthma, which is involved in the pathogenesis of asthma. The determination of serum NO can be used as an index to judge the therapeutic effect.