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目的探讨GPER1基因rs10269151位点SNP多态性与流产之间的相关性。方法采用SNa Pshot法对117例自然流产汉族女性和107例对照组女性GPER1基因rs10269151位点进行的基因分型,采用SHEsis进行遗传分析,探讨其基因型和等位基因的频率分布差异。结果 rs10269151位点病例组基因型频率AA 85%、AG 6.84%、GG 92.31%,病例组AA 0.85%、AG6.84%、GG 92.31%,p Value>0.05;病例组等位基因频率A 4.27%、G95.73%,对照组3.27%,96.73%,p Value>0.05。结论GPER1基因rs10269151位点与自然流产之间缺乏关联性。
Objective To investigate the association between SNP polymorphism at rs10269151 site of GPER1 and abortion. Methods SNa Pshot method was used to genotype rs10269151 in 117 women with spontaneous abortion and 107 women with normal controls. The frequency of genotypes and alleles was analyzed by SHEsis. Results The genotype frequencies of rs10269151 locus were AA 85%, AG 6.84%, GG 92.31%, cases AA 0.85%, AG 6.84%, GG 92.31%, p value> 0.05. The frequency of allele A was 4.27% , G95.73%, control group 3.27%, 96.73%, p Value> 0.05. Conclusion There is no correlation between GPER1 rs10269151 locus and spontaneous abortion.