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Ca~(2+)参与壁细胞三个泌酸受体——组胺H_2受体、胃泌素受体和乙酰胆碱M_2受体兴奋过程的多个环节。钙通道阻滞剂可能通过抑制H~+-K~+ATP酶即质子泵等机制减少胃酸分泌,因而可用于预防胃粘膜损伤、治疗消化性溃疡。
Ca ~ (2+) is involved in various processes of excitability of three oxytocin receptors - histamine H 2 receptor, gastrin receptor and acetylcholine M 2 receptor in parietal cells. Calcium channel blockers may reduce gastric acid secretion by inhibiting H ~ + -K ~ + ATPase, proton pump and other mechanisms, which can be used to prevent gastric mucosal injury and treat peptic ulcer.