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应用组织培养技术对非癌性胃疾病粘膜组织分泌性免疫球蛋白A(SIgA)体外合成分泌水平进行测定,发现慢性浅表性胃炎组(4.35±0.32μg/mg)和慢性萎缩性胃炎组(4.82±0.22μg/mg)SIgA分泌量均高于正常组(2.76±0.21μg/mg),P<0.01。正常组胃窦粘膜SIgA(3.31±0.32μg/mg)高于胃体分泌量(2.31±0.29μg/mg),P<0.05。慢性浅表性胃炎与萎缩性胃炎组间及其胃窦与胃体之间SIgA分泌量无明显差异。慢性胃炎患者SIgA体外合成分泌量增高提示胃粘膜炎症促使SIgA排泄增多,以加强胃粘膜的免疫保护作用。
The in vitro synthesis and secretion of secretory immunoglobulin A (SIgA) in mucosal tissues from non-cancerous gastric diseases were measured using tissue culture techniques. The chronic superficial gastritis group (4.35±0.32 μg/mg) and chronic atrophic gastritis groups were found. The secretion of SIgA in 4.82±0.22μg/mg was higher than that in normal group (2.76±0.21μg/mg), P<0.01. In the normal group, the gastric mucosal SIgA (3.31±0.32 μg/mg) was higher than the gastric body secretion (2.31±0.29 μg/mg), P<0.05. There was no significant difference in the amount of SIgA secretion between chronic superficial gastritis and atrophic gastritis groups and between antrum and gastric body. Increased secretion of SIgA in vitro in patients with chronic gastritis prompted increased gastric mucosal inflammation to promote SIgA excretion, in order to strengthen the gastric mucosal immune protection.