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[目的]观察黄芪益肾汤联合西药治疗糖尿病肾病疗效。[方法]使用随机平行对照方法,将66例门诊及住院患者按就诊顺序号法简单随机分为两组。控制饮食,低盐、低蛋白、低油脂为主,常食用水果、蔬菜,保证充足睡眠。对照组33例预混胰岛素,50mg/次,1次/d,皮下注射;缬沙坦,80mg/次,1次/d。治疗组33例黄芪益肾汤(黄芪、淫羊藿15g,生白术10g,生大黄5g,晚蚕沙10g,土茯苓、白茅根各15g,川芎6g,赤芍10g,郁金6g,石菖蒲10g),1剂/d,水煎400m L,早晚冲服,200m L/次;西药治疗同对照组。连续治疗30d为1疗程。观测临床症状、FPG、UAER、SCr、不良反应。治疗1疗程,判定疗效。[结果]治疗组显效13例,有效27例,无效3例,总有效率90.91%。对照组显效9例,有效13例,无效11例,总有效率66.67%。治疗组疗效优于对照组(P<0.05)。血液指标两组均有改善(P<0.05),治疗组改善优于对照组(P<0.05)。[结论]黄芪益肾汤联合西药治疗糖尿病肾病疗效满意,无严重不良反应,值得推广。
[Objective] To observe the therapeutic effect of Huangqi Yishen Decoction combined with western medicine on diabetic nephropathy. [Methods] Using randomized parallel control method, 66 cases of outpatients and inpatients were randomly divided into two groups according to the sequence number of attendance. Control diet, low salt, low protein, low fat-based, often eating fruits and vegetables, to ensure adequate sleep. Control group, 33 cases of premixed insulin, 50mg / time, 1 times / d, subcutaneous injection; valsartan, 80mg / time, 1 time / d. The treatment group, 33 cases of Astragalus Yishen Decoction (Astragalus, Epimedium 15g, Atractylodes 10g, rhubarb 5g, late silkworm excrement 10g, Smilax, Rhizoma Imperatae each 15g, Chuanxiong 6g, red peony root 10g, turmeric 6g, Shichangpu 10g), 1 dose / d, decoction 400m L, morning and evening blunt, 200m L / times; western medicine treatment with the control group. Continuous treatment of 30d for a course of treatment. Observed clinical symptoms, FPG, UAER, SCr, adverse reactions. Treatment of a course of treatment to determine the efficacy. [Results] In the treatment group, 13 cases were markedly effective, 27 cases were effective, 3 cases were ineffective, and the total effective rate was 90.91%. In the control group, 9 cases were markedly effective, 13 cases were effective and 11 cases were ineffective. The total effective rate was 66.67%. The treatment group was better than the control group (P <0.05). Blood index improved in both groups (P <0.05), and treatment group improved better than control group (P <0.05). [Conclusion] Astragalus Yishen Decoction combined with western medicine has a satisfactory curative effect on diabetic nephropathy without serious adverse reactions and is worth promoting.