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应用Ｎｏｒｔｈｅｒｎ杂交技术发现遗传听源惊厥易感大鼠Ｐ７７ＰＭＣ在出生１４天后脑内ｃ－ｆｏｓｍＲ－ＮＡ水平迅速增高，２１天达到最高水平，而后逐渐下降，此与大鼠惊厥易感性形成规律相类似；惊厥后脑内ｃ－ｆｏｓｍＲＮＡ具有快速、大量及一过性表达特点；惊厥前后１５分钟内给予安定（１０ｍｇ／ｋｇ）能有效阻断ｃ－ｆｏｓ基因表达。推测ｃ－ｆｏｓ基因间接地参与了Ｐ７７ＰＭＣ大鼠惊厥易感性的形成。
Northern blotting showed that the level of c-fosmR-NA in rat brain was significantly increased after 14 days of birth, reaching the highest level in 21 days and then gradually decreasing, which was similar to the formation of seizure susceptibility in rats The c-fos mRNA expression in brain was fast, large and transient after convulsion. Apo (10 mg / kg) within 15 minutes before and after convulsion could effectively block the expression of c-fos gene. It is speculated that c-fos gene indirectly involved in the formation of seizure susceptibility in P77PMC rats.