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儿童急性淋巴细胞白血病(ALL)化疗后的完全缓解率可达90％～100％。长期缓解者为70％,30％复发。对于儿童ALL第一次复发经诱导二次缓解后采用自身骨髓移植和化疗的效果尚不清楚作者通过配对研究结果如下。 病人和方法 德国协作组自1983年4月至1994年10月间从889例儿童ALL第一次复发者中各选择52例配对比较。两组的性别、诊断时年龄、复发时间、免疫细胞学分型均相同。第二次诱导缓解后,化疗组每口口服硫鸟嘌呤,每二周静脉注射氨甲喋呤一次。共2年;自身骨髓移植组32例行全身放疗加足叶乙甙(VP_(16))或/和环磷酰胺,20例接受大剂量的联合化疗,方案为VP_(16)、环磷酰胺、马利兰或噻(口替)哌;有15例骨髓移植前应用单克隆抗体等方法行骨髓净化,其余的未净化。
The complete remission rate of children with acute lymphoblastic leukemia (ALL) chemotherapy after chemotherapy up to 90% to 100%. Long-term relief of 70%, 30% recurrence. The effect of using its own bone marrow transplant and chemotherapy after induction of second remission for the first relapse of pediatric ALL is unclear. The results of the paired studies are as follows. PATIENTS AND METHODS The German collaborative team selected 52 paired comparisons from the first relapse of 889 children with ALL between April 1983 and October 1994. The two groups of gender, age at diagnosis, recurrence time, immunocytotyping are the same. After the second induction of remission, each group oral thioguanine chemotherapy, intravenous methotrexate once every two weeks. A total of 32 cases of bone marrow transplantation group were treated with systemic radiotherapy plus etoposide (VP_ (16)) and / or cyclophosphamide, 20 cases received high-dose combination chemotherapy, the program for the VP_ (16), cyclophosphamide , Maryland or thiazide (oral replacement) piperazine; 15 cases of bone marrow transplantation before the application of monoclonal antibody and other methods of bone marrow purification, the rest is not clean.