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[目的]了解女性不孕症患者支原体感染状况及对抗生素的耐药情况,指导临床合理用药。[方法]选择柳州地区不孕妇女332例,其中原发不孕138例,继发不孕194例,并选择120例正常生育妇女做对照,取宫颈分泌物做Uu、Mh检测,并对阳性者做药敏试验。[结果]不孕症患者支原体阳性率45.2%,与对照组比较差异有统计学意义(P﹤0.05);继发不孕组与原发不孕组相比,支原体阳性率无差异(P﹥0.05);支原体感染以Uu为主,Uu+Mh次之;Uu对美满霉素、强力霉素、交沙霉素、环脂红霉素较敏感,Uu+Mh对美满霉素、强力霉素较敏感,它们可用于支原体感染的治疗;Uu+Mh感染的耐药率升高,多重耐药现象严重;Uu对4种抗生素耐药所占比例最高(26.2%),Uu+Mh对10种抗生素耐药所占比例最高(50%),Uu、Uu+Mh对抗生素的耐药种数不一致。[结论]柳州地区不孕症患者支原体感染率高,且多重耐药,但对强力霉素、美满霉素较敏感。
[Objective] To understand the status of mycoplasma infection and the resistance to antibiotics in women with infertility and to guide clinical rational drug use. [Methods] 332 cases of infertile women were selected in Liuzhou area, including 138 cases of primary infertility, 194 cases of secondary infertility, 120 cases of normal fertility women as controls, cervical secretions for Uu and Mh detection, and positive Do drug susceptibility testing. [Results] The positive rate of mycoplasma in infertility patients was 45.2%, which was significantly different from that in control group (P <0.05). There was no difference in the positive rate of mycoplasma between infertility group and primary infertile group (P> 0.05). Uu was the main mycoplasma infection, followed by Uu + Mh. Uu was more sensitive to minocycline, doxycycline, jasamycin, and rosiglitazone. Uu + Mh was sensitive to minocycline, doxycycline, Uu + Mh infection rate was increased, the multi-drug resistance was serious; Uu accounted for the highest proportion of four antibiotic resistance (26.2%), Uu + Mh against 10 The highest proportion of antibiotic resistance (50%), Uu, Uu + Mh antibiotic resistant species is inconsistent. [Conclusion] The prevalence of mycoplasma in infertility patients in Liuzhou area is high and multi-drug resistant, but it is more sensitive to doxycycline and minocycline.