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目的探讨采用中西药联合治疗抑郁症的疗效，完善临床应用。方法2013年6月~2014年12月于我院就诊的抑郁症患者80例，随机分为观察组和对照组各40例。对照组患者采用西药西酞普兰口服治疗，观察组患者在口服西酞普兰的基础上加用中药联合治疗，对两组患者的治疗效果和预后情况进行对比分析。结果观察组患者的治疗有效率及痊愈率均高于对照组，两组对比差异有统计学意义(<0.05)；观察组药物治疗后1周末、2周末副反应强度显著小于对照组，两组对比差异有统计学意义(<0.05)。结论采用中西药联合治疗抑郁症能提高治疗效果，减轻副反应，治疗上安全、有效，应用价值高，值得在临床工作中加以推广应用。“,”Objective To explore the usage of the integrative medicine on depression, for improving clinical application. Methods 80 patients were randomly divided into observation group and control group of 40 cases. Patients in the control group were treated with oral medicine citalopram, the observation group was given citalopram oral medicine more. The treatment and prognosis in two groups were analyzed. Results The ef iciency and recovery rates in the observation group were higher, the dif erence between two groups was statistical y significant ( <0.05);strength of side ef ects in the observation were significantly smal er after 1 week and 2 weeks observation, the dif erence was statistical y significant ( <0.05). Conclusion The integrative medicine can improve the therapeutic ef ect and reduce side ef ects. It is safe, ef ective and valuable, it is worth to be popularized in clinical.