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目的:研究断乳大鼠铁强化膳食对其成年高脂膳食诱导肥胖后血清瘦素水平的影响。方法:将85只初断乳雄性SD大鼠随机分为基础饲料组和高(4倍)、中(3倍)、低(2倍)剂量铁强化组。4周后各组均以基础饲料喂养1周,于第5周末测定大鼠体脂和血清瘦素含量。将基础饲料组16只大鼠随机分为正常对照组和肥胖诱导组,肥胖诱导组和3个铁强化组均喂以高脂饲料。高脂干预8周后处死所有大鼠计算脂/体比,检测血清瘦素含量。结果:高脂干预后,肥胖诱导组体重、体脂含量、瘦素水平均高于其他各组,3个铁强化组瘦素含量高于正常对照组。结论:生命早期适量补铁能够促进大鼠成年期肥胖诱导后的脂肪分解,维持大鼠体重平衡,保证机体瘦素分泌及功能正常。
Objective: To investigate the effect of iron fortified diet on the level of serum leptin in adult high fat diet-induced obesity rats. Methods: Eighty-eight weaned male Sprague-Dawley rats were randomly divided into basal diet group and high (4 times), medium (3 times) and low (2 times) doses of iron fortification group. Four weeks later, each group was fed with basal diet for one week. At the end of the fifth week, body fat and serum leptin levels in rats were determined. Sixteen rats in the basal diet group were randomly divided into normal control group and obesity induction group. Fat-induced group and three iron-fortified group were fed with high-fat diet. After 8 weeks of high-fat intervention, all rats were sacrificed to calculate the lipid / body ratio, and serum leptin levels were measured. Results: Body weight, body fat content and leptin level in obesity induction group were higher than those in other groups after high-fat diet intervention. Leptin content in three iron-fortified groups was higher than that in normal control group. Conclusion: Early iron supplementation in early life can promote fat breakdown induced by obesity in adult rats, maintain body weight balance and ensure leptin secretion and normal function in the body.