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观察了一种醛糖还原酶抑制剂(ICI 128436)对小鼠胰岛体外培养时山梨醇代谢的影响情况。小鼠胰岛培养72小时后,酶抑制剂处理过的胰岛山梨醇水平较对照组显著降低。结果表明小鼠胰岛可以合成山梨醇,其生成水平与醛糖还原酶的活性密切有关。
The effect of an aldose reductase inhibitor (ICI 128436) on the sorbitol metabolism in mouse islets cultured in vitro was observed. After pancreatic islet cells were cultured for 72 hours, the inhibitor of pancreatic islet sorbitol was significantly lower than that of the control group. The results show that mouse islets can be synthesized sorbitol, the level of its production is closely related to the activity of aldose reductase.