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15-甲-PGF_(2α)和13-去氢-ω 乙-PGF_(2α)在相同剂量时均能使妊娠7天的大鼠血浆孕酮浓度下降。15-甲-PGF_(α2)组于用药后4、8和24小时血浆孕酮浓度下降,分别为用药前的56.6%、43.7%和13.3%。在给药后72小时所有动物子宫中胚胎已被吸收。13-去氢ω-乙-PGF_(2α)组于用药后4、8和24小时血浆孕酮浓度分别为用药前的63.5%、34.4%和51.9%,给药后72小时大多数动物子宫中仍有胚胎,但胚胎比对照组显著为小,且多游离于子宫中。在给15-甲-PGF_(2α)前30分钟和第二次给15-甲-PGF_(2α)的同时,肌注 HOG 20国际单位,能完全对抗15-甲-PGF_(2α)的降低妊娠大鼠血浆孕酮浓度和抗早孕作用,给药后24小时内血浆孕酮浓度与对照组相似,全部动物维持妊娠,胚胎大小和数目也与对照组相似。恒速静注15-甲-PGF_(2α)(20微克)于麻醉妊娠大鼠,30分钟后已使子宫卵巢静脉血中孕酮含量由用药前1.271±0.154微克/10分钟下降到0.279±0.083微克/10分钟,给药后60分钟仍维持于低水平。如预先静注 HOG 20国际单位,可使子宫卵巢静脉血中孕酮含量由用药前1.123±0.162微克/10分钟升高到1.496±0.018微克/10分钟,在 HCG作用的基础上再静脉恒速注入15-甲-PGF_(2α),虽可使子宫卵巢静脉血中孕酮含量下降到1.179±0.042微克/10分钟,但不能降低到
15-A-PGF_ (2α) and 13-Dehydro-ω B-PGF_ (2α) all decreased plasma progesterone concentrations in rats at 7 days of gestation at the same dose. Plasma progesterone concentrations in 15-A-PGF_ (α2) group decreased at 56, 43 and 13.3%, respectively, at 4, 8 and 24 hours after treatment. All animal embryos were taken up 72 hours after dosing. The plasma progesterone concentrations of the 13-dehydrogenated ω-B-PGF 2α group were 63.5%, 34.4% and 51.9% at 4, 8 and 24 hours after administration, respectively. Most of the animals had uterus There are still embryos, but the embryos are significantly smaller than the control and more free in the uterus. In the meantime, HOG 20 intramuscular injection was able to completely antagonize the 15-A-PGF 2α reduction of pregnancy, 30 minutes before 15-A-PGF 2α and 15-A-PGF 2α a second time Plasma progesterone concentration and anti-early pregnancy effect in rats, within 24 hours after administration of plasma progesterone concentrations similar to the control group, all animals to maintain pregnancy, embryo size and number also similar to the control group. After 30 minutes, the progesterone level in uterine ovary venous blood was decreased from 1.271 ± 0.154 μg / 10 min before treatment to 0.279 ± 0.083 Micrograms / 10 minutes, 60 minutes after administration remained at low levels. Pretreatment with HOG 20 as an international unit increased the progesterone level in the uterine ovarian vein from 1.123 ± 0.162 μg / 10 min to 1.496 ± 0.018 μg / 10 min before administration, Injection of 15-A-PGF_ (2α), although the uterine ovarian blood progesterone levels dropped to 1.179 ± 0.042 micrograms / 10 minutes, but can not be reduced to