川崎病(Kawasaki disease,KD)是儿童急性自限性全身血管炎症综合征,以冠状动脉受损为主。目前川崎病的病因、发病机制尚不明确。而KD患儿急性期与中性粒细胞有关的流行病学资料、病理学改变、中性粒细胞酶及抗中性粒细胞胞浆酶抗体的变化,以及针对中性粒细胞治疗的有效性,均提示中性粒细胞参与KD急性期冠状动脉损伤。该文就中性粒细胞在川崎病血管损伤中作用进行了文献综述。 Kawasaki disease (KD) is a children’s acute self-limiting systemic vascular inflammation syndrome, mainly coronary artery damage. The cause of Kawasaki disease, the pathogenesis is not yet clear. However, the epidemiological data of neutrophils in acute KD children, pathological changes, changes of neutrophil enzyme and anti-neutrophil cytoplasmic antibody, and the effectiveness of neutrophil therapy , All suggest that neutrophils are involved in acute KD coronary artery injury. This article reviews the literature on the role of neutrophils in vascular injury in Kawasaki disease.