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目的探讨门冬氨酸鸟氨酸对伴有肝炎肝硬化肝癌患者围手术期肝脏功能及术后并发症的影响.方法选取肝癌患者68例,随机法分为对照组32例和研究组36例.对照组给予常规护肝治疗.研究组在对照组治疗措施的基础上,术前3d开始应用门冬氨酸鸟氨酸,术后连续用药7d.分别于术前1d和术后1、3、7d空腹测定外周静脉血血清ALT、AST、胆红素、血氨含量.结果研究组ALT、AST、血氨水平低于对照组相应的术前1d、术后1、3、7d水平,差异有统计学意义(P0.05).对照组术后并发症发生率明显高于研究组(P<0.05).结论门冬氨酸鸟氨酸对行手术治疗的伴有肝炎肝硬化肝癌患者具有提高肝脏功能储备作用,促进术后肝脏功能恢复及减少术后并发症发生.“,”Objective To investigate the protective effects of L-Ornithine-L-Aspartate on liver function in patients after liver resection.Methods Sixty-eight patients undergoing liver resection were randomly divided into study group and control group.Control group was treated to the conventional therapy and study group had conventional therapy and L-Ornithine-L-Aspartate for injection intravenously from the third day before operation to the seven day after operation.The alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL),direct bilirubin(DBIL) and blood ammonia(BA) levels were determined before operation and on days 1,3 and 7 after operation.Results On days 1 before operation,days 1,3 and 7 after operation,ALT and AST levels in the study group were significantly lower than those in the control group(P<0.05).The complications of postoperation in study group were lower than in control group(P<0.05).Conclusion L-Ornithine-L-Aspartate can alleviate the hepatic dysfunction after hepatectomy and decrease the complications of postoperation.