论文部分内容阅读
目的研究盐酸二甲双胍缓释片体内外相关性。方法应用释放度测定法研究盐酸二甲双胍缓释片的体外释药行为;用HPLC法测定盐酸二甲双胍缓释片在人体内的血药浓度;采用脱卷积法计算体内释放特性,与相应的体外释药特性进行比较。结果盐酸二甲双胍缓释片体外释放百分率和体内吸收百分率的相关性良好(r=0.910 3)。结论脱卷积法适用于盐酸二甲双胍缓释片的体内外相关性研究。
Objective To study the in vitro and in vivo correlation of metformin hydrochloride sustained-release tablets. Methods The release of metformin hydrochloride sustained-release tablets was studied in vitro. The plasma concentration of metformin hydrochloride sustained-release tablets in human was determined by HPLC method. The in vitro release characteristics of metformin hydrochloride sustained- Drug characteristics were compared. Results Metformin hydrochloride sustained-release tablets in vitro release percentage and in vivo absorption percentage correlation was good (r = 0.910 3). Conclusions The deconvolution method is suitable for in vitro and in vivo correlation of metformin hydrochloride sustained-release tablets.