论文部分内容阅读
内皮素(Endothelin,ET)是一种由21个氨基酸组成的活性多肽。近年来的研究表明,肺部的许多组织中均有ET及其受体,对肺通气功能和肺循环起重要的调、节作用,且与许多肺部疾病密切相关。本文就有关问题进行综述。 1 ET及其受体在肺部的分布及表达现已证明,人和动物体内存在4种ET,即ET-1、ET-2、ET-3和血管活性肠肽(VIC),用分子生物学及免疫组化发现肺组织中含有ETmRNA和内皮素免疫活性物质(ir-ET)。在人、小鼠和大鼠气道上皮的粘液细胞,
Endothelin (ET) is a 21 amino acid active polypeptide. In recent years, studies have shown that many tissues in the lungs have ET and its receptors, pulmonary ventilation and pulmonary circulation play an important role in the regulation, and is closely related to many lung diseases. This article summarizes the related issues. 1 Distribution and expression of ET and its receptors in the lungs It has been shown that there are four kinds of ET in humans and animals, ET-1, ET-2, ET-3 and vasoactive intestinal peptide (VIC) Learning and immunohistochemistry found that lung tissue contains ETmRNA and endothelin immunoreactive substances (ir-ET). Mucous cells in human, mouse and rat airway epithelium,