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中西药配伍联用在治疗急慢性疾病中发挥了不可低估的作用,但由于中药成分复杂,与西药配伍后可使药效降低或产生毒副作用,也有发生死亡的报道,应引起重视。 1 产生络合物,妨碍吸收,影响疗效 ①牛黄解毒片与四环素类抗生素同用,牛黄解毒片中石膏的主要成分为硫酸钙,钙离子可与四环素类药物分子内的酰胺基和酚基结合,形成难于在肠道内吸收的络合物四环素钙,从而降低二者疗效。②牛黄解毒片与
Combination of Chinese and Western medicine in the treatment of acute and chronic diseases play an important role can not be underestimated, but due to the complex composition of traditional Chinese medicine, compatibility with Western medicine can reduce efficacy or toxic side effects, there have been reports of death should be taken seriously. 1 complex, hinder the absorption, affect the efficacy of ① Niuhuangjiedu tablets and tetracycline antibiotics with the same, Niuhuangjiedu tablets in the main component of gypsum calcium sulfate, calcium and tetracycline drugs with amide and phenolic groups , Forming complex tetracycline calcium, which is difficult to be absorbed in the intestine, thereby reducing the curative effect of both. ② Niuhuang detoxification tablets and