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目的:探讨胎球蛋白-A(fetuin-A,FA)与2型糖尿病患者动脉粥样硬化的相关性。方法:将60例糖尿病患者按颈动脉内膜中膜厚度(IMT)分为2组,糖尿病伴动脉粥样硬化组33例,IMT≥0.9 mm,或有1个以上动脉粥样硬化斑块;糖尿病不伴动脉粥样硬化组27例,IMT<0.9 mm,无动脉粥样硬化斑块。另设正常对照组(20例)。所有对象均测定FA、IMT。结果:糖尿病两组FA值较正常对照组增高,差异均有统计学意义(P<0.05);糖尿病伴动脉粥样硬化组FA值高于糖尿病不伴动脉粥样硬化组,差异有统计学意义(P<0.05)。两组FA值与IMT呈正相关。结论:FA在糖尿病动脉粥样硬化患者血清中显著升高,可作为糖尿病动脉粥样硬化的监测指标。
Objective: To investigate the relationship between fetuin-A (FA) and atherosclerosis in type 2 diabetic patients. Methods: Sixty diabetic patients were divided into two groups according to carotid intima - media thickness (IMT), 33 with diabetes mellitus with atherosclerosis group, IMT ≥ 0.9 mm, or with at least one atherosclerotic plaque. Twenty-seven patients with diabetes without atherosclerosis had an IMT of <0.9 mm and no atherosclerotic plaques. Another normal control group (20 cases). All subjects were measured FA, IMT. Results: Compared with normal control group, the FA value of the two groups of diabetes mellitus increased (P <0.05), and the FA value of diabetic patients with atherosclerosis group was higher than that of diabetic patients without atherosclerosis group, the difference was statistically significant (P <0.05). FA values of both groups were positively correlated with IMT. Conclusion: FA is significantly increased in the sera of diabetic patients with atherosclerosis, which can be used as a monitoring indicator of atherosclerosis in diabetic patients.