血小板激活因子(platclet activating factor,PAF)是一种具有广泛生物学活性的内源性脂质因子,最初发现于家兔嗜碱粒细胞中,因能激活血小板引起组胺释放而命名,其化学结构为1-0-烷基-2-乙酰基-Sn-甘油-3-磷脂酰胆碱。PAF作用于多种组织细胞和器官,参与机体病理生理过程,在炎症、休克、哮喘、溃疡等疾病的发生中起重要作用,并参与雄性生殖与妊娠。 1 PAF的来源、生成及生物学效应 The platclet activating factor (PAF) is a kind of endogenous lipid factor with a wide range of biological activities. It was originally found in rabbit basophil cells and named after activating platelets to cause histamine release. Its chemical The structure is 1-0-alkyl-2-acetyl-Sn-glycero-3-phosphatidylcholine. PAF acts on many kinds of tissues, cells and organs and participates in the pathophysiological process of the body. PAF plays an important role in the occurrence of diseases such as inflammation, shock, asthma and ulcer, and participates in male reproduction and pregnancy. 1 PAF origin, production and biological effects