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目的 探讨各年龄组儿童正常血清铋浓度及服用治疗剂量胶体次枸橼酸铋（ＣＢＳ）的安全性。方法 用原子荧光光谱法测定９７ 例１～１２ 岁正常儿童血清铋浓度和９４ 例５ ～１２ 岁经胃镜检查确诊为幽门螺杆菌（Ｈｐ）相关性胃十二指肠疾病的儿童，服ＣＢＳ６ 周，合并阿莫仙和甲硝唑各服２ 周的治疗方案后，进行服ＣＢＳ后１、２、４、６ 周和停服后１ 周、１～２ 个月、３～４ 个月、５～６ 个月和６ ～１２ 个月以上血清铋浓度的观察。结果 （１）正常儿童血清铋浓度在各组间经统计，Ｆ＝ １３．７５，Ｐ＝０．０００ １，差异有非常显著意义。本组正常儿童血铋浓度从１ 岁始随年龄增长而增高，５～６ 岁组到１２ 岁保持相对恒定。（２）服ＣＢＳ后各组血清铋浓度经统计，Ｆ＝３７．１８，Ｐ＝０．０００ １，其中４ 周、６ 周两组与１ 周、２ 周两组间差异有显著意义（ Ｐ＜ ０．０５），服药后血铋浓度逐渐上升，４ 周后不再继续升高，平均在（１０．２ ±２．４）μｇ／Ｌ或（１０．８±２．１） μｇ／Ｌ，远未达到临界浓度（５０～１００ μｇ／Ｌ）。（３）停药后各组血铋浓度经统计，Ｆ＝２２．１１，Ｐ＜０．０００ １，各组均数间两两比较差异也有显著意义（ Ｐ＜ ０．０５），可见服Ｃ
Objective To investigate the serum levels of bismuth in normal children and the safety of taking colloidal bismuth citrate (CBS) at a therapeutic dosage. Methods Serum bismuth concentrations in 97 normal children aged 1-12 years and 94 children aged 5-12 years old diagnosed as Helicobacter pylori (Hp) related gastroduodenal diseases by gastroscopy were measured by atomic fluorescence spectrometry. CBS 6 weeks , Combined with amoxicillin and metronidazole for 2 weeks each treatment program, after 1, 2, 4, 6 weeks after CBS and 1 week after stopping, 1 to 2 months, 3 to 4 months, 5 ~ 6 months and 6 ~ 12 months serum bismuth concentrations observed. Results (1) The serum bismuth concentration in normal children was statistically calculated among groups, F = 13.75, P = 0.000 1, the difference was significant. This group of normal children’s blood bismuth concentrations from 1 year old increased with age, 5 to 6-year-old group to 12-year-old remained relatively constant. (2) Serum bismuth concentration in each group after taking CBS was statistically significant (F = 37.18, P = 0.0001), and there was significant difference between the two groups at 4 weeks, 6 weeks and 1 week and 2 weeks (P <0.05). The blood bismuth concentration increased gradually after taking the drug and no longer increased after 4 weeks, with an average of (10.2 ± 2.4) μg / L or (10.8 ± 2.1) μg / L , Far below the critical concentration (50 ~ 100 μg / L). (3) after stopping the blood bismuth concentration in each group by statistics, F = 22.11, P <0.000 1, the average number of each group was significantly different between each other (P <0.05)