用放射线照射减弱的曼氏血吸虫尾蚴免疫小鼠,再以正常尾蚴攻击感染免疫小鼠,在攻击感染后第一天和第六天分别给予吡喹酮治疗的研究结果证明,在抗攻击感染方面,免疫和化疗之间存在着协同作用。本研究的目的就是在于了解这种协同作用的组织病理学变化和寄生虫损伤的性质。CBA鼠分为两组,一组以γ射线照射曼氏血吸虫尾蚴所制备的尾蚴活疫苗免疫,另一组不免疫作为对 Mice immunized with attenuated Schistosoma mansoni cercariae were immunized with normal cercariae to challenge immunized mice and praziquantel treatment was administered on the first and sixth days after the challenge, respectively. The results of the study demonstrate that in the anti-challenge infection There is synergy between immunization and chemotherapy. The purpose of this study is to understand the synergistic histopathological changes and the nature of parasitic lesions. CBA mice were divided into two groups, one of which was immunized with γ-rays irradiated cercaria larvae of cercariae, and the other group was immunized as