The BL19U2 at the Shanghai Synchrotron Radiation Facility is a small-angle X-ray scattering beamline dedicated to structural studies pertaining to bio-logical macromolecules in solution. The beamline has been officially opened to users in March 2015, and since then, a series of technological innovations has been developed to optimize beamline performance, thereby significantly improving the data collection efficiency and broadening the application scope of biological small-angle X-ray scatter-ing. BL19U2 is ideal for the high-throughput screening of weakly scattered proteins, protein assemblies, nucleic acids, inorganic nanomaterials, and organic drug mole-cules. This paper describes the design and overview of the BL19U2 beamline. Versatile sample environments at the experimental station and some recent scientific highlights are presented.