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研究红霉素 (ERY)在老年人体内过程的特点。方法 以年轻志愿者为对照 ,研究ERY在老年人中的药物动力学。10名老年志愿者 (老年组 )和 8名年轻志愿者 (年轻组 )分别单剂量空腹 poERY肠溶微粒胶囊 5 0 0mg后 ,采用微生物法测定血、尿药物浓度 ,计算药物动力学参数。结果 老年组poERY 5 0 0mg后其cmax、tmax、T1/ 2 β和AUC分别为 3.0 4mg/L、2 .98h、2 .5 5h和 14.5 8(mg/L) ,给药后 2 4h时累积尿排出率为 4.2 8%。结论 老年组poERY后吸收较年轻组为缓慢 ,AUC值较年轻组增高 ,两组间差异有统计学意义 (P <0 .0 5 ) ,cmax、T1/ 2 β和尿排出率等两组间差异无统计学意义 (P >0 .0 5 )。
To study the process of erythromycin (ERY) in the elderly. Methods Young volunteers as a control study ERY pharmacokinetics in the elderly. Ten elderly volunteers (aged group) and eight young volunteers (young group) were given a single dose of fasting poery enteric-coated capsules 500 mg respectively, and the blood and urine drug concentrations were determined by the microbiological method to calculate the pharmacokinetic parameters. Results The cmax, tmax, T1 / 2 β and AUC in the elderly group were 3.0 4 mg / L, 2.98 h, 2.55 h and 14.58 (mg / L) Urinary excretion rate was 4.2%. Conclusions The post-poore absorption of the aged group is slower than that of the younger group, and the AUC value is higher in the elderly group than in the younger group (P <0.05). The differences of cmax, T1 / 2 β and urinary excretion rates between the two groups were statistically significant The difference was not statistically significant (P> 0.05).