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目的:探讨前列腺蛋白(Prostasin)和紧密连接蛋白3(Claudin-3)在卵巢上皮性癌中的表达及临床意义。方法:采用免疫组化SP法检测Prostasin和Claudin-3在50例卵巢上皮性癌、20例卵巢交界性肿瘤、20例卵巢良性肿瘤、20例正常卵巢组织中的表达情况。结果:Prostasin和Claudin-3在卵巢上皮性癌中的表达均明显高于其他三组(P<0.05),二者在卵巢上皮性癌中的表达与组织病理分级、临床分期有关(P<0.05),与组织学分型无关(P>0.05);Prostasin和Claudin-3在卵巢上皮性癌中的表达呈正相关(r=0.386,P<0.05)。结论:Prostasin和Claudin-3的表达升高与卵巢上皮性癌的发生、发展密切相关,Prostasin和Claudin-3有可能成为治疗卵巢癌的新靶点。
Objective: To investigate the expression and clinical significance of Prostasin and Claudin-3 in epithelial ovarian cancer. Methods: The expressions of Prostasin and Claudin-3 in 50 cases of ovarian epithelial carcinoma, 20 cases of ovarian borderline tumor, 20 cases of benign ovarian tumor and 20 cases of normal ovarian tissue were detected by immunohistochemical SP method. Results: The expressions of Prostasin and Claudin-3 in epithelial ovarian cancer were significantly higher than those in the other three groups (P <0.05). The expression of Prostasin and Claudin-3 in ovarian epithelial carcinoma was correlated with histopathological grade and clinical stage (P <0.05 ), But not histological type (P> 0.05). The positive expression of Prostasin and Claudin-3 in epithelial ovarian cancer was significantly higher than that in normal ovarian tissues (r = 0.386, P <0.05). CONCLUSIONS: Prostasin and Claudin-3 expression are closely related to the occurrence and development of epithelial ovarian cancer. Prostasin and Claudin-3 may become new targets for the treatment of ovarian cancer.