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目的 提高对韦格内肉芽肿病 (Wegenergranucomatosis,WG)的认识 ,并对它诊断和鉴别诊断及治疗加以探讨。方法 回顾分析自 1978- 1997年 14例韦格内肉芽肿的临床资料及文献复习。结果 14例韦格内肉芽肿 ,12例经病理学证实 ,2例根据血清CANCA( + )结合临床症状及治疗确诊。结论 韦格内肉芽肿诊断方法主要靠病理活检 ,临床症状、X线、CT、MR、化验室辅查 ,其中抗嗜中性粒细胞胞浆抗体 (CANCA)是WG的特异性抗体。病理以小血管纤维坏死及巨细胞肉芽肿为特征
Objective To improve the understanding of Wegener’s granulomatosis (WG) and to probe its diagnosis and differential diagnosis and treatment. Methods The clinical data and literature reviews of 14 Wegener’s granulomas from 1978 to 1997 were reviewed. Results Wegner’s granulomatosis was found in 14 cases, 12 cases were confirmed by pathology and 2 cases were diagnosed according to CANCA (+) combined with clinical symptoms and treatment. Conclusion The diagnosis of Wegener’s granulomatosis mainly depends on pathological biopsy, clinical symptoms, X-ray, CT, MR and laboratory tests. Among them, anti-neutrophil cytoplasmic antibody (CANCA) is a specific antibody of WG. Pathology is characterized by small vessel fibrosis and giant cell granulomas