地西他滨(5氮-2′-脱氧胞苷,商品名DACOGEN)为胞嘧啶类似物,特异的甲基化转移酶抑制剂,可逆转DNA的甲基化过程,激活沉默失活的抑癌基因,是DNA低甲基化药物中的一种。DNA低甲基化药物包括两种:5氮胞苷和5氮-2′-脱氧胞苷,地西他滨属于后者。美国食品药品管理局(FDA)早在2006年5 Decitabine (5-aza-2’-deoxycytidine under the trade name DACOGEN) is a cytosine analogue, a specific inhibitor of methylated transferase, which reverses DNA methylation and activates silencing inactivation Oncogene, one of the DNA hypomethylation drugs. DNA hypomethylation drugs include two: 5-azacytidine and 5-azo-2’-deoxycytidine, decitabine belongs to the latter. US Food and Drug Administration (FDA) as early as 2006 5