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超速激活延迟整流钾电流(IKur)是一种在人心房肌细胞特异性表达,而心室肌不表达(或低表达)的离子通道。IKur参与心房复极的Ⅰ相和Ⅱ相,通过影响心房肌细胞动作电位时程(action potential duration,APD)和有效不应期(effective refractory period,ERP)而影响心房的正常节律和频率,它的电活动异常与心房颤动(简称房颤,atrial fibrillation,AF)的发生和维持有着密切关系。近年来,对IKur的分子结构、功能研究
Overspeed Activation Delayed Rectifier Potassium Current (IKur) is an ion channel that is specifically expressed in human atrial myocytes and is not expressed (or downregulated) in the ventricular muscle. IKur participates in atrial repolarization phase I and phase II and affects atrial rhythm and frequency through influencing atrial myocytes’ action potential duration (APD) and effective refractory period (ERP) The abnormal electrical activity is closely related to the occurrence and maintenance of atrial fibrillation (AF). In recent years, IKur’s molecular structure and function studies