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目的:探讨三维适形再程放疗同步联合奈达铂(NDP)加氟尿嘧啶(5-Fu)治疗放疗后复发食管癌的疗效。方法:收集2010年1月至2011年1月,我院收治的放疗后复发食管癌60例,随机分为观察组与对照组,各30例。对照组实施三维适形再程放疗序贯NDP治疗,放疗结束后应用NDP+5-Fu化疗,观察组实施三维适形再程放疗同步联合NDP治疗,放疗中及放疗后配以NDP+5-Fu化疗,比较两组的疗效。结果:观察组的近期疗效总有效率为63.3%,与对照组的56.7%比较无明显差异(P>0.05);观察组的1、2、3年生存率显著高于对照组(P<0.05);观察组的血液系统毒副反应率较对照组显著升高(P<0.05),两组非血液系统毒副反应及放射性食管炎无明显差异(P>0.05)。结论:三维适形再程放疗同步联合NDP+5-Fu治疗放疗后复发食管癌疗效显著,有利于提高患者的生存率,具有一定的临床应用价值。
Objective: To investigate the curative effect of three-dimensional conformal reradiation combined with NDP and 5-Fu in the treatment of recurrent esophageal cancer after radiotherapy. Methods: From January 2010 to January 2011, 60 cases of recurrent esophageal cancer after radiotherapy in our hospital were collected and randomly divided into observation group and control group, with 30 cases in each group. The control group was treated with three-dimensional conformal radiotherapy (NDP) and NDP + 5-Fu chemotherapy. The observation group was treated with three-dimensional conformal radiotherapy combined with NDP. Radiotherapy and radiotherapy followed by NDP + 5- Fu chemotherapy, the efficacy of the two groups were compared. Results: The total effective rate in the observation group was 63.3%, which was not significantly different from 56.7% in the control group (P> 0.05). The 1, 2, 3-year survival rates in the observation group were significantly higher than those in the control group ). The hematological toxicity rate in the observation group was significantly higher than that in the control group (P <0.05). There was no significant difference between the two groups in the side effects of non-hematological system and esophagitis (P> 0.05). Conclusions: Three-dimensional conformal rehospital radiotherapy combined with NDP + 5-Fu in the treatment of recurrent esophageal cancer after radiotherapy has a significant effect, which is beneficial to improve the survival rate of patients and has certain clinical value.