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目的研究中枢５－ＨＴ能神经在焦虑症中的作用机制。方法用同位素配基结合技术测定大鼠脑皮质５－ＨＴ２Ａ和５－ＨＴ１Ｂ受体结合力。结果间氯苯哌嗪（ｍ－Ｃｈｌｏｒｏｐｈｅｎｙｌｐｉｐｅｒａｚｉｎｅ，ｍＣＰＰ）减少大鼠脑皮质５－ＨＴ２Ａ受体结合力，对５－ＨＴ１Ｂ受体结合力无影响。结论中枢５－ＨＴ能神经的变化在焦虑症的发病机制中具有一定的作用。
Objective To study the mechanism of central 5-HT nerves in anxiety disorders. Methods The binding of 5-HT2A and 5-HT1B receptors in rat cerebral cortex was determined by isotope ligand binding assay. Results m-Chlorophenylpiperazine (mCPP) decreased the binding capacity of 5-HT2A receptor in rat cerebral cortex and had no effect on the binding capacity of 5-HT1B receptor. Conclusion The changes of central 5-HT nerve can play a certain role in the pathogenesis of anxiety.