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目的:探讨分析在超声引导下采用未成熟卵泡抽吸术(IMFA)的治疗方法对多囊卵巢综合征(PCOS)合并不孕的患者卵巢窦卵泡计数和内分泌功能的影响。方法:选择2008年3月~2011年3月该院生殖医学中心收治的46例PCOS不孕患者,超声引导下对所有患者行IMFA,对比观察IMFA治疗前后患者卵巢窦卵泡计数和内分泌功能的变化,同时观察卵巢排卵功能的恢复情况及妊娠情况。结果:46例PCOS不孕患者经过2~3个周期的IMFA治疗后,患者睾酮(T)水平明显降低、黄体生成素(LH)和卵泡刺激素(FSH)比值也显著降低,与治疗前对比,差异具有统计学意义(P<0.05)。术后有37例患者卵巢窦卵泡计数降低至10个以下;术后对患者连续随访半年,共有22例患者成功妊娠。结论:IMFA能显著降低PCOS不孕患者的卵巢窦卵泡计数,并且能显著改善内分泌状况,可以作为PCOS不孕患者一种有效可行的治疗方法。
Objective: To investigate the effects of ultrasound-guided treatment of immature follicular aspiration (I-FFA) on ovarian antral follicle count and endocrine function in patients with polycystic ovary syndrome (PCOS) and infertility. Methods: From March 2008 to March 2011, 46 cases of PCOS infertile patients admitted to Reproductive Medicine Center of our hospital were enrolled. All patients underwent IMFA under ultrasound guidance. Changes of ovarian antral follicle count and endocrine function were observed before and after IMFA treatment , While observing ovarian ovulation recovery and pregnancy status. Results: In 46 cases of infertility with PCOS, the level of testosterone (T) and the ratio of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were significantly decreased after 2 to 3 cycles of IMFA treatment. Compared with those before treatment , The difference was statistically significant (P <0.05). 37 cases of patients with ovarian antral follicle count down to 10 or less; after continuous follow-up of patients for six months, a total of 22 patients with successful pregnancy. Conclusion: IMFA can significantly reduce ovarian antral follicle count in patients with PCOS infertility, and can significantly improve the endocrine status, which can be used as an effective and feasible treatment for infertility patients with PCOS.