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目的：探讨ｐ１６ 、ｎｍ２３ 、ｃｍｙｃ 基因蛋白在胃癌组织中的表达及其临床意义。方法：应用免疫组化技术对６０ 例胃癌内镜活检组织进行检测，结合术后标本的病理学指标进行分析。结果：ｐ１６ 、ｎｍ２３ 和ｃｙｃ 基因蛋白在胃癌中的阳性表达分别是４３３ ％ 、６５ ％ 、５８３ ％ 。ｐ１６ 与胃癌组织学类型及分化程度密切相关，分化高者ｐ１６ 阳性表达率高；ｎｍ２３ 与胃癌的淋巴转移密切相关，ｎｍ ２３ 阳性组其淋巴结转移率（５８９ ％ ） 明显低于ｎｍ２３ 阴性组（８５７ ％ ） ；ｃｍｙｃ 与胃癌的浸润深度密切相关，而与淋巴转移及分化无相关性。结论：三项基因在胃癌的发生发展中起着重要的正负调控作用，通过内镜活检组织检测ｐ１６ 、ｎｍ ２３ 、ｃｍｙｃ 基因蛋白可在术前获得更多的反映肿瘤生物学特性的指标，对临床治疗方案的选择、预后估计有重要意义。
Objective: To investigate the expression and clinical significance of p16, nm23 and cmyc genes in gastric cancer. Methods: Immunohistochemical technique was used to detect endoscopic biopsy of 60 cases of gastric cancer, and the pathological features of the specimens were analyzed. Results: The positive expressions of p16, nm23 and cyc genes in gastric cancer were 43. 3%, 65%, and 58. 3%, respectively. P16 is closely related to the histological type and degree of differentiation of gastric cancer. The positive expression rate of p16 is higher in those with high differentiation; nm23 is closely related to lymph node metastasis in gastric cancer; the lymph node metastasis rate in the nm23-positive group is significantly lower than that in the nm23-negative group (58.9%). (85 7 %); c myc is closely related to the depth of gastric cancer invasion, but not related to lymph node metastasis and differentiation. Conclusion: The three genes play an important role in the occurrence and development of gastric cancer. Detection of p16, nm23 and cmyc by endoscopic biopsy can obtain more biological characteristics before surgery. The indicators are important for the selection of clinical treatment options and the estimation of prognosis.