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目的比较表阿霉素 (组 )、长春新碱 (组 )分别联合卡铂、VP16超选择动脉灌注化疗治疗脑恶性肿瘤的疗效及并发症。方法超选择动脉灌注化疗治疗脑恶性肿瘤 3 0例 ,随机使用表阿霉素 (组 )、长春新碱 (组 )分别联合卡铂、VP16治疗并比较其疗效。结果两组有效率 (CR+ PR)分别为 5 5 .6% (10 / 18)和 5 8.3 % (7/ 12 ) (P>0 .0 5 ) ,均无严重并发症。结论两组联合治疗方案的疗效相当 ,但表阿霉素组脱发更为明显 ,且价格昂贵 ,临床应用受一定限制
Objective To compare the efficacy and complications of epirubicin (group) and vincristine (group) with carboplatin and VP16 superselective arterial infusion chemotherapy in the treatment of malignant brain tumors. Methods Thirty patients with malignant brain tumors were selected by transcatheter arterial infusion chemotherapy. Epirubicin (group) and vincristine (group) were treated with carboplatin and VP16 respectively. The curative effect was compared. Results The effective rates (CR + PR) of the two groups were 55.6% (10/18) and 53.3% (7/12), respectively (P> 0.05). There were no serious complications. Conclusions The efficacy of the two combination regimens is comparable, but the epirubicin group is more prone to hair loss and is expensive, with limited clinical application