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目的:探讨FAT4基因单核苷酸多态性与江苏人群胃癌遗传易感性的关系。方法:采用人群为基础的病例对照研究对来自江苏的783例经组织病理学确诊的胃癌新发病例和按照性别年龄匹配的855例健康对照,利用实时荧光定量PCR(realtime PCR)方法对FAT4基因上非同义氨基酸多态性位点进行基因分型,比较各位点不同基因型与胃癌发病风险的关系。结果:利用Logistic回归模型在相加模型中进行了分析的结果显示,在调整性别、年龄、吸烟和饮酒等因素后,携带rs1039808 A等位基因的个体胃癌发病风险显著低于携带野生纯合子(GG)的个体(OR=0.74,95%CI:0.62~0.88,P=0.001)。分层分析显示,在各亚组间rs1039808不同基因型与胃癌发病风险的关联强度没有显著差异。结论:FAT4基因单核苷酸多态性rs1039808 A等位基因能显著降低胃癌发病风险。
Objective: To investigate the relationship between single nucleotide polymorphism of FAT4 gene and genetic susceptibility to gastric cancer in Jiangsu population. METHODS: A population-based case-control study of 783 newly diagnosed cases of gastric cancer from Jiangsu Province and 855 healthy controls by sex-age-matched controls was performed on real-time PCR for FAT4 gene On the non-synonymous amino acid polymorphism loci genotypes, comparison of different loci genotypes and the risk of gastric cancer. Results: Logistic regression model was used to analyze the additive model. The results showed that the incidence of gastric cancer with rs1039808 A allele was significantly lower than that with wild homozygotes (P <0.05) after adjusting for gender, age, smoking and drinking, GG) (OR = 0.74, 95% CI: 0.62-0.88, P = 0.001). Hierarchical analysis showed no significant difference in the association between different genotypes of rs1039808 and the risk of gastric cancer in each subgroup. Conclusion: Single nucleotide polymorphism rs1039808 A allele of FAT4 gene can significantly reduce the risk of gastric cancer.