Dear Editor,rnThe electroneutral K+-Cl-cotransporters(KCCs)play fundamental roles in trans-epithelial transport,cell volume regulation,and neuronal excitability.1 The neuronal-specific KCC2(SLC12A5)and glial-expressed KCC3(SLC12A6)are essential for normal develop-ment and function of the nervous system.Mutations in KCC2 have been linked with human idiopathic generalized epilepsy2 and schizophrenia.3 KCC3-dependent Cl-transport across the choroid plexus epithelia is involved in the production of cerebrospinal fluid.