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目的:研究孕期抗凝血Ⅲ(AT-Ⅲ)活性的变化及其与妊娠期急性脂肪肝(AFLP)的关系。方法:以2008年7月至2014年7月我科住院分娩的AFLP孕妇24例为研究组,同期住院分娩的正常孕妇30例为对照组,比较两组间及组内早孕期(12-14周)、中孕期(26-28周)、晚孕期(34-36周)AT-Ⅲ活性的变化。结果:随着孕周的发展,AT-Ⅲ活性逐渐降低(P<0.05);两组早孕期AT-Ⅲ活性无明显差异(P>0.05),研究组中、晚孕期AT-Ⅲ活性较对照组明显降低[(94.40±11.09)%vs(103.98±12.34)%,(70.61±13.80)%vs(89.05±10.30)%,P<0.05)];中、晚孕期AT-Ⅲ活性诊断AFLP的界值分别是86.20%及96.10%。结论:中、晚孕期AFLP患者血浆AT-Ⅲ活性明显降低,AT-Ⅲ活性分别低于86.20%及96.10%时可预测AFLP的发生。
Objective: To study the changes of the activity of anticoagulant blood Ⅲ (AT-Ⅲ) during pregnancy and its relationship with acute fatty liver of pregnancy (AFLP). Methods: From July 2008 to July 2014, 24 pregnant women with AFLP who were hospitalized in our department were selected as the research group. 30 normal pregnant women delivered in hospital during the same period were compared. The control group was compared between the two groups and the early pregnancy (12-14 Weeks), during pregnancy (26-28 weeks), late pregnancy (34-36 weeks) AT-III activity changes. Results: AT-Ⅲ activity gradually decreased with the development of gestational age (P <0.05). There was no significant difference in AT-Ⅲ activity between the two groups in early pregnancy (P> 0.05) Group (94.40 ± 11.09)% vs (103.98 ± 12.34)%, (70.61 ± 13.80)% vs (89.05 ± 10.30)%, P <0.05) The values were 86.20% and 96.10% respectively. CONCLUSION: The AT-Ⅲ activity in plasma of AFLP patients in the second and third trimester of pregnancy is significantly lower than that of the first trimester AFLP. The ATL activity is predicted to be less than 86.20% and 96.10% respectively.