本文采用免疫组化技术,从93年初开始前瞻性研究了乳腺癌孕激素受体测定,指导治疗及生物学意义。至94年底共检测175例乳腺癌,其中孕激素受体(PR)阳性122例,阴性53例,PR阳性表达率69.71％。经统计学分析,PR阳性率与病人年龄、月经状况、肿瘤大小、临床分期、淋巴结有无转移及病理组织类型无显著相关性(P>0.05)。PR测定的意义在于指导临床选择治疗方案和判定预后。 In this article, immunohistochemical technique was used to prospectively study the progesterone receptors of breast cancer from the beginning of the year 93 to guide the treatment and biological significance. By the end of 1994, a total of 175 cases of breast cancer were detected, including 122 progesterone receptor (PR) positive and 53 negative, PR positive expression rate of 69.71%. After statistical analysis, the positive rate of PR was not significantly associated with the patient’s age, menstrual status, tumor size, clinical stage, lymph node metastasis, and pathological type (P>0.05). The significance of PR measurement is to guide the clinical choice of treatment plan and determine the prognosis.