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目的:探讨格列吡嗪控释片在老年2型糖尿病(T2DM)患者中应用的有效性和安全性。方法:老年T2DM患者160例随机分为治疗组与对照组各80例,治疗组采用采用格列吡嗪控释片治疗,对照组采用二甲双胍治疗。比较两组患者治疗前后空腹血糖(FBG)及餐后2 h血糖(F2BG),以及总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL)等指标变化。结果:治疗后,两组患者FBG、F2BG、TG、TC、LDL等指标均较治疗前明显下降(P<0.05),治疗后治疗组下降趋势明显大于对照组(P<0.05)。结论:相对于二甲双胍,格列吡嗪控释片能有效降低老年T2DM患者血糖与血脂含量,安全性好,值得推广应用。
Objective: To investigate the efficacy and safety of glipizide controlled-release tablets in elderly patients with type 2 diabetes mellitus (T2DM). Methods: 160 elderly patients with T2DM were randomly divided into treatment group and control group of 80 cases, the treatment group were treated with glipizide controlled release tablets, the control group was treated with metformin. Fasting blood glucose (FBG), 2 h postprandial blood glucose (F2BG) and changes of total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (LDL) were compared between the two groups before and after treatment. Results: After treatment, the FBG, F2BG, TG, TC, LDL and other indexes were significantly decreased in both groups (P <0.05). After treatment, the decline trend of the treatment group was significantly greater than that of the control group (P <0.05). Conclusion: Compared with metformin, glipizide controlled-release tablets can effectively reduce blood glucose and blood lipid levels in elderly patients with T2DM, which is safe and worthy of promotion.