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目的:观察血小板4项参数(BPC血小板计数、MPV血小板平均体积、PCT血小板比积、PDW血小板分布宽度)在SIRS(全身炎症反应综合征)发展过程中的变化趋势及其临床意义。方法:对正常对照组、SIRS组(未达MODS)和MODS(多器官功能障碍综合征)组进行PLT、MPV、PCT、PDW记录与统计分析;同时也记录S组(南非SIRS发展到SIRS的病人但未达到MODS者)、M组(由SIRS发展到MODS者)的病人4项参数变化,进行自身对照,统计分析结果:对照组BPC(×10~9/L)为200.72±52.09,MPV(n)为10.03±1.83,PCT(%)为0.1991±00.0564,PDW(%SD)为17.59±0.94;SIRS组分别为121.94±44.46、10.98±2.34、0.1263±00.0396、17.57±1.64;MODS组分别为51.74±24.55、10.75±2.54、0.0674±0.0454、18.77±2.45;其中BPC和PCT三组对比均有显著性差异(p<0.05)。SIRS组和对照组MPV比较有显著性差异(P<0.05)。MODS组和对照组、SIRS组的PDW比较均有显著性差异(P<0.05)。S组4项参数前后差值为-125.55±60.66(P<0.001)、1.116±1.944(p=0.000)、-0.0953±0.0696(P<0.000)、0.2370±1.3767(P=0.249);M组4项参数前后差值为-67.54±42.23(P<0.000)、0.7629±1.9071(P<0.05)、-0.0453±-0.0392(P<0.001)、1.886±1.912(P<0.001)。结论:在SIRS发展过程中,PLT、PCT进行性下降,MPV、PDW逐渐上升,SIRS病人上述变化趋势提示病情加重。
OBJECTIVE: To observe the change trend and clinical significance of four platelet parameters (BPC platelet count, MPV platelet volume, PCT platelet volume and PDW platelet distribution width) in the development of SIRS (systemic inflammatory response syndrome). Methods: The normal control group, SIRS group (less than MODS) and MODS (multiple organ dysfunction syndrome) group were recorded and statistically analyzed by PLT, MPV, PCT, PDW and S group (SIRS in South Africa to SIRS Patients with MODS), M group (patients with MODS developed from SIRS), self-control were performed. Statistical analysis results showed that BPC (× 10 ~ 9 / L) in control group was 200.72 ± 52.09 and MPV (n = 10.03 ± 1.83, PCT (%) = 0.1991 ± 00.0564, PDW (% SD) = 17.59 ± 0.94, respectively; SIRS group was 121.94 ± 44.46,10.98 ± 2.34,0.1263 ± 0.0.0396,17.57 ± 1.64 respectively; (51.74 ± 24.55,10.75 ± 2.54,0.0674 ± 0.0454,18.77 ± 2.45). There was significant difference between BPC and PCT (p <0.05). There was significant difference in MPV between SIRS group and control group (P <0.05). There was significant difference in PDW between MODS group and control group and SIRS group (P <0.05). The differences of the four parameters in S group were -125.55 ± 60.66 (P <0.001), 1.116 ± 1.944 (P = 0.000), -0.0953 ± 0.0696 (P <0.0001) and 0.2370 ± 1.3767 The difference between the two parameters was -67.54 ± 42.23 (P <0.000), 0.7629 ± 1.9071 (P <0.05), -0.0453 ± -0.0392 (P <0.001) and 1.886 ± 1.912 (P <0.001) respectively. Conclusion: During the development of SIRS, PLT and PCT decreased progressively, MPV and PDW gradually increased, and the above-mentioned trends of SIRS patients suggested that the disease progressed.