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目的探讨粘附分子上皮钙粘素 (E cadherih ,E CD)在肺癌组织中的表达及与生物学行为的关系。方法应用免疫组织学SP法研究 1 5例肺慢性支气管炎症及 40例肺癌组织中E CD的表达。结果肺慢性支气管炎症及肺癌组织中E CD的阳性表达率分别为 80 % (1 2 1 5例 )、40 % (1 6 40例 ) ,两者差异有显著性意义 (P <0 0 1 ) ;同时E CD在肺癌组织中的表达与其分化程度、浸润深度、淋巴结转移及临床分期等有相关关系 (P <0 0 5 0 0 1 )。结论E CD参与了肿瘤的发生、发展、浸润及转移
Objective To investigate the expression of adhesion molecule E-cadherin (E CD) in lung cancer and its relationship with biological behavior. Methods Immunohistochemical SP method was used to study the expression of E CD in 15 cases of chronic bronchial inflammation and 40 cases of lung cancer. Results The positive expression rates of ECD in chronic lung bronchitis and lung cancer tissues were 80% (1515 cases) and 40% (1640 cases), respectively. There was a significant difference between the two groups (P<0 01). At the same time, the expression of E CD in lung cancer was related to its differentiation, depth of invasion, lymph node metastasis and clinical stage (P <0 0 5 0 1). Conclusion E CD is involved in the occurrence, development, invasion and metastasis of tumors